Juvenile hormone analogs as in vitro inhibitors of rat liver microsomal oxidases.

Three juvenile hormone analogs were found to be in vitro inhibitors of rat liver microsomal oxidases. Aniline hydroxylase reactions gave apparent inhibition constants of 8 X 10-5 M and 1.4 X 10 4 M for ( E ) -4[( 6,7 -epoxy-3,7 dimethyl2monenyl)oxy] 1,2(methylenedioxy) benzene and (E) 4 [(6,7 epoxy 3 ethyl 7 methyl 2 noneny1)oxyl 1,2 (methylenedioxy)benzene, respectively. (E)-6,7-Epoxy-l-(p-ethylphenoxy)-3,7dimethyl-2-octene, the least active, had an apparent inhibition constant of 2.5 X M. Cytochrome P-450 binding for all three compounds was observed to be of the type I category. The results provide evidence that J H analogs react with mammalian tissues and are thus not completely insect specific.